Our research goals are to elucidate the mechanisms by which diet and nutrition affects drug metabolism, chemical toxicity, and carcinogenesis. The mechanistic studies in the lab are also being extended to field work on the nutritional prevention of human cancers.
Specific Research Projects
- Molecular mechanisms by which tea plyphenols, isothiocyanates (from cruciferous vegetables), and allyl sulfide (from garlic) inhibit carcinogenesis and chemical toxicity. The contribution of oxidative cellular damage to the development of esophageal adenocarcinoma, especially under iron overload situations, in a surgically induced reflux model in rats; related mechanistic studies with human tissue samples. he roles of alterations of tumor suppressor gene p53, Rb, and p16 in esophageal carcinogenesis.
- Collaborative human studies to determine whether tea consumption lowers the risk of esophageal, colon, stomach, and prostate cancers.
Please visit: http://molbiosci.rutgers.edu/faculty/yang.html